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Sputum and oral microbiota profiles are associated with long COVID severity and phenotype post-hospitalisation: a UK multicentre, prospective cohort study — Headley et al

"the study recruited patients aged 18 years or older who were discharged from one of 83 NHS hospitals in the UK" "We observed distinct oral and sputum microbiota profiles with very severe ongoing health impairments and with Long COVID subgroups."

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https://publications.ersnet.org/content/erj/early/2026/10/09/1399300301162-2026

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Oral Fluid Inflammatory Biomarker Profile in Long COVID: Evaluation of Oral Active and Total MMP-8, MMP-9, and TIMP-1 in Relation to BMI and Disease Status — Aji et al

"These findings suggest altered oral protease regulation in LC, while the concurrent increase in TIMP-1 may reflect a compensatory antiprotease response."

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https://www.ijidonline.com/article/S1201-9712(26)00818-0/abstract

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Long COVID is associated with lipoxygenase-catalyzed metabolism of essential polyunsaturated fatty acids — Moss et al

"we present data demonstrating that plasma 12-LO-derived metabolites were significantly increased during acute SARS-CoV2 infection in participants who went on to develop LC, and that this […] was independent of initial infection severity."

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https://www.cell.com/iscience/abstract/S2589-0042(26)02960-3

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Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVID — Painter et al

"These features are consistent with the presence of exhausted or partially exhausted spike-specific CD8 T cells in a subset of patients with LC and are indicative of chronic stimulation by a persistent reservoir of SARS-CoV2."

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https://www.biorxiv.org/content/10.64898/2026.10.14.759221v1

bioRxivPersistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVIDLong COVID (LC) affects millions of people worldwide, yet its driving mechanisms remain incompletely defined and no treatment has been approved. Persistence of SARS-CoV-2 and reactivation of herpesviruses have been implicated in LC, but direct detection of these viral antigens in blood and tissues has been challenging. T cells are exquisitely sensitive to viral antigens, survey organs throughout t
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Measures of Overall Illness Severity and Burden for ME/CFS: A Scoping Review — Cripe et al

"Our review indicates that studies vary widely in how illness severity and burden in ME/CFS are operationalized."

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https://link.springer.com/article/10.1007/s40271-026-00849-8

SpringerLinkMeasures of Overall Illness Severity and Burden for ME/CFS: A Scoping Review - The Patient - Patient-Centered Outcomes ResearchBackground and Objectives Consensus has not been established on measures of illness severity and burden for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), which is characterized by a wide range of symptoms including post-exertional malaise, unrefreshing sleep, and cognitive impairment. A scoping review was conducted to systematically evaluate the measurement of illness severity and b
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